Pyrrolidine → 2-{2-[(5-Bromo-2-fluoro-phenyl)-pyrrolidin-1-yl-methyl]-pyrrol-1-yl}-thiobenzamide
반응식
[N:1]1([C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8]([NH2:10])=[S:9])[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl-].[Br:16][C:17]1[CH:18]=[CH:19][C:20]([F:29])=[C:21]([CH:28]=1)[CH:22]=[N+:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1.BrC1C=CC(F)=C(C=1)C=O.N1CCCC1>>[Br:16][C:17]1[CH:18]=[CH:19][C:20]([F:29])=[C:21]([CH:22]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)[C:5]2[N:1]([C:6]3[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=3[C:8]([NH2:10])=[S:9])[CH:2]=[CH:3][CH:4]=2)[CH:28]=1참가 물질
5
실험 절차
The preparation was carried out in accordance with general synthesis instructions 4 from 2-pyrrol-1-yl-thiobenzamide and 1-(5-bromo-2-fluoro-benzylidene)-pyrrolidinium chloride, which had been prepared in accordance with example 4 from 5-bromo-2-fluorobenzaldehyde and pyrrolidine.