Lithium hydroxide, monohydrate → HCID 178524764, 화합물
반응식
[OH:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][N:5]=[CH:4][N:3]=1.O[Li].O>C1COCC1.CO>[OH:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[CH:4][N:3]=1참가 물질
5
실험 절차
Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5 mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec). 4-Hydroxy-2-Methylpyrimidine-5-Carboxylic Acid (20).
후처리
- customThe mixture was quenched with conc. HCl (1 mL)
- extractionextracted with EtOAc (2×20 mL)
- extractionThe combined organic extract
- dry with materialwas dried (MgSO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-9927cbbdc3ea494198370d244d84e72f
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07034035B2
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