Dimethyl Sulfate → 6-[2-(4-Methoxy-phenyl)-vinyl]-pyridine-2-carbonitrile
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N+:12]=2[O-])=[CH:5][CH:4]=1.COS(OC)(=O)=O.[C-:25]#[N:26].[Na+]>C(O)(C)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]2[N:12]=[C:13]([C:25]#[N:26])[CH:14]=[CH:15][CH:16]=2)=[CH:5][CH:4]=1참가 물질
5
실험 절차
Following the general method described in example 2b, 2-[2-(4-methoxy-phenyl)-vinyl]-pyridine 1-oxide was reacted first with dimethylsulfate and then with NaCN. After extraction and crystallization the title compound was obtained as a yellow crystalline material. Mp. 121–122° C. (isopropanol), MS: m/e=236 (M+)
후처리
- extractionAfter extraction and crystallization the title compound
- customwas obtained as a yellow crystalline material
출처 및 근거
- ORD 기록
- ord-4823032ef01440d4b8de2bfb09759748
- 출처 데이터셋
- uspto-grants-2006_04
- 특허 번호
- US07034044B2
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