p-Toluenesulfonic acid → 2-(2-((2-Bromobenzyl)oxy)ethoxy)tetrahydro-2H-pyran

HRID 1797288노트

반응식

HRID 1797288 반응식
[Br:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10]OC1CCCCO1.[O:22]1C=C[CH2:25][CH2:24][CH2:23]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1COCC1>[Br:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][O:8][CH:9]1[CH2:10][CH2:25][CH2:24][CH2:23][O:22]1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 99469012-(2-(2-((2-Bromobenzyl)oxy)ethoxy)ethoxy)tetrahydro-2H-pyran

생성물 1

HCID 98798912-(2-((2-Bromobenzyl)oxy)ethoxy)tetrahydro-2H-pyran

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The reaction and work up was conducted as described in the preparation of compound 420. Starting materials were compound 417 (8.0 g, 34.9 mmol) in 20 mL dry THF, 3,4-dihydro-2H-pyran (3.2 mL, 34.9 mmol) and p-toluenesulfonic acid (0.14 g, 0.76 mmol) and the reaction time was 4 h. The crude product was purified by flash chromatography using EtOAc/petroleum ether 1:2 as the eluent to afford the title compound as a colourless oil.

후처리

  1. customThe reaction and work
  2. customThe crude product was purified by flash chromatography

출처 및 근거

ORD 기록
ord-d7373535b1aa415e9b08da7c5f3d7216
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07034015B2

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