Water → 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile

HRID 1797397노트

반응식

HRID 1797397 반응식
[Si:1]([CH2:8][CH2:9][C@H:10]([O:16]C(=O)C)[C:11]([CH3:15])([CH3:14])[C:12]#[N:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[OH-].[Na+].O>C(O)C>[Si:1]([CH2:8][CH2:9][C@H:10]([OH:16])[C:11]([CH3:15])([CH3:14])[C:12]#[N:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 23567930HCID 23567930, 화합물

생성물 1

HCID 235679315-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
25 °C

실험 절차

4.8 g (16 mmol) of 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)-acetoxy-pentane-nitrile is dissolved in 50 ml of ethanol and mixed with 1.28 g of NaOH (32 mmol). It is stirred for 3 hours at 25° C., added to 200 ml of water, extracted with 2×200 ml of MTB ether, dried on sodium sulfate and concentrated by evaporation.

후처리

  1. extractionextracted with 2×200 ml of MTB ether
  2. customdried on sodium sulfate
  3. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-d9b61283b4764852b750c87d580f40ea
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07034165B2

반응 노트

불러오는 중…