Hydrochloric Acid → HCID 60206182, 화합물
반응식
[CH2:1]([O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:16]3[S:17][CH:18]=[C:19]([C:21]([OH:23])=[O:22])[N:20]=3)[CH:14]=2)[C:9](=[O:24])[N:8]([CH2:25][CH:26]([CH3:28])[CH3:27])[C:7]=1[CH2:29][NH:30]C(OC(C)(C)C)=O)[CH2:2][CH2:3][CH3:4].[ClH:38]>C(OCC)(=O)C>[ClH:38].[NH2:30][CH2:29][C:7]1[N:8]([CH2:25][CH:26]([CH3:27])[CH3:28])[C:9](=[O:24])[C:10]2[C:15]([C:6]=1[O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[CH:14][C:13]([C:16]1[S:17][CH:18]=[C:19]([C:21]([OH:23])=[O:22])[N:20]=1)=[CH:12][CH:11]=2참가 물질
4
실험 절차
2-[4-Butoxy-3-[[(tert-butoxycarbonyl)amino]methyl]-2-isobutyl-1-oxo-1,2-dihydro-6-isoquinolinyl]-1,3-thiazole-4-carboxylic acid (0.16 g, 0.3 mmol) was dissolved in a solution of 4N hydrogen chloride in ethyl acetate (5 ml) and the mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure and the residue was crystallized from ethyl acetate to give 2-[3-(aminomethyl)-4-butoxy-2-isobutyl-1-oxo-1,2-dihydro-6-isoquinolinyl]-1,3-thiazole-4-carboxylic acid hydrochloride (0.13 g, 92.9%) as crystals.