Hydrochloric Acid → 2,4-Dihydroxy-6-methoxymethyl-benzaldehyde

HRID 1798059노트

반응식

HRID 1798059 반응식
COC[O:4][C:5]1[CH:12]=[C:11]([O:13]COC)[CH:10]=[C:9]([CH2:17][O:18][CH3:19])[C:6]=1[CH:7]=[O:8].Cl>C1COCC1.CCOC(C)=O>[OH:4][C:5]1[CH:12]=[C:11]([OH:13])[CH:10]=[C:9]([CH2:17][O:18][CH3:19])[C:6]=1[CH:7]=[O:8]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 582925712,4-Bis-methoxymethoxy-6-methoxymethyl-benzaldehyde

생성물 1

HCID 582926702,4-Dihydroxy-6-methoxymethyl-benzaldehyde수율 100%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2,4-bis-methoxymethoxy-6-methoxymethyl-benzaldehyde (3.93 g, 14.45 mmol) in THF (30 mL) was added 6 N HCl (10 mL). The mixture was stirred at room temperature for 20 hours then diluted with EtOAc (200 mL). The mixture was washed with brine, dried and concentrated to give 2,4-dihydroxy-6-methoxymethyl-benzaldehyde (2.62 g, 100%). 1H NMR (400 MHz, CDCl3δ 12.40 (s, 1H), 10.10 (s, 1H), 6.41 (s, 1H), 6.30 (s, 1H), 5.60 (s, 1H), 4.61 (s, 2H), 3.40 (s, 3H).

후처리

  1. washThe mixture was washed with brine
  2. customdried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-38a82620bfd6499eaee3241cfee20708
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08343944B2

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