1-Methoxy-3-(methylsulfonyl)benzene → 3-(Methylsulfonyl)phenol

HRID 1798799

반응식

HRID 1798799 반응식
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9]([CH3:12])(=[O:11])=[O:10])[CH:4]=1>Br.C(O)(=O)C>[CH3:12][S:9]([C:5]1[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][CH:6]=1)(=[O:10])=[O:11]

참가 물질

4

반응물 1

HCID 2596501-Methoxy-3-(methylsulfonyl)benzene

생성물 1

HCID 6375563-(Methylsulfonyl)phenol

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매

실험 절차

1-Methoxy-3-(methylsulfonyl)benzene (300 mg, 1.61 mmol) was suspended in 1.6 mL aqueous hydrobromic acid (48% w/w) and 1.6 mL acetic acid. The mixture was heated under reflux for 24 hours. The reaction was cooled back to room temperature and concentrated. The residue was purified by column chromatography through a 40 gram biotage silica gel cartridge eluting with 40-70% ethyl acetate/hexanes (gradient) to give the product as white solid. LRMS calc: 172.0; obs: 173.2 (M+1).

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography through a 40 gram biotage silica gel cartridge
  5. washeluting with 40-70% ethyl acetate/hexanes (gradient)

출처 및 근거

ORD 기록
ord-11b48ec471dc4eb293cd2916ea000e55
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08343990B2

연결된 노트

불러오는 중…