Methyl iodide → N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine

HRID 1801850노트

반응식

HRID 1801850 반응식
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]3[C:16]([CH:17]=2)=[N:15][N:14]([CH3:18])[C:13]=3[CH3:19])[CH:5]=[CH:4][N:3]=1.[C:20](=O)([O-])[O-].[Cs+].[Cs+].IC>CN(C=O)C>[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH3:20])[C:9]2[CH:10]=[CH:11][C:12]3[C:16]([CH:17]=2)=[N:15][N:14]([CH3:18])[C:13]=3[CH3:19])[CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 11637631N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine

생성물 1

HCID 11608962N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine수율 37%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine (2.21 g; 8 mmol, 1 equiv) was dissolved in DMF (11 ml) and cesium carbonate (7.9 g; 24.2 mmol, 3 equiv) was added. The reaction mixture was stirred for 30 min under nitrogen. Iodomethane (0.8 ml, 13 mmol, 1.6 equiv) was added and the reaction mixture was stirred at room temperature for 2 hrs. The reaction mixture was poured in ice cold water and stirred for 30 minutes. The resulting precipitate was collected by filtration to yield the desired compound (0.84 g, 37%).

후처리

  1. stirringthe reaction mixture was stirred at room temperature for 2 hrs
  2. additionThe reaction mixture was poured in ice cold water
  3. stirringstirred for 30 minutes
  4. filtrationThe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-2a481b647c3c45d780f7e2948ea83963
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349861B2

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