Hydrochloric Acid → 2-Morpholino-[1,2,4]triazolo[1,5-a]pyridin-7-amine hydrochloride

반응식

[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:23]=[C:10]3[CH:11]=[C:12]([NH:15]C(=O)OC(C)(C)C)[CH:13]=[CH:14][N:9]3[N:8]=2)[CH2:3][CH2:2]1.[ClH:24]>>[ClH:24].[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[N:23]=[C:10]3[CH:11]=[C:12]([NH2:15])[CH:13]=[CH:14][N:9]3[N:8]=2)[CH2:5][CH2:6]1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 67776770HCID 67776770, 화합물

생성물 1

HCID 677759312-Morpholino-[1,2,4]triazolo[1,5-a]pyridin-7-amine hydrochloride수율 108.5%

반응 조건

온도: 25 °C

실험 절차

A mixture of tert-butyl 2-morpholino-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate (356 mg, 1.11 mmol) and hydrochloric acid (6N in ether, 10 ml, 60.0 mmol) is stirred for 2 hours at 25° C. The solvent is removed in vacuo affording 2-morpholino-[1,2,4]triazolo[1,5-a]pyridin-7-amine hydrochloride (308 mg, 108%) as a light yellow solid. mp.: >250° C. MS: m/z=220.3 (M+H+).

후처리

customThe solvent is removed in vacuo

출처 및 근거

ORD 기록: ord-8277f5862e3f4e35bb5052258e042087
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08349824B2

반응 노트

불러오는 중…