Hydrochloric Acid → 2-(Pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-amine
반응식
[N:1]1([C:6]2[N:22]=[C:9]3[CH:10]=[C:11]([NH:14]C(=O)OC(C)(C)C)[CH:12]=[CH:13][N:8]3[N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>ClCCl>[N:1]1([C:6]2[N:22]=[C:9]3[CH:10]=[C:11]([NH2:14])[CH:12]=[CH:13][N:8]3[N:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
A mixture of tert-butyl 2-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamate (340 mg, 1.12 mmol) and hydrochloric acid (5N in ether, 25 ml, 125 mmol) in dichloromethane (10 ml) was stirred for 20 hours at 25° C. The solvent was evaporated, the residue was triturated with sat. sodium hydrogencarbonate solution, the solid was filtered off, washed with water several times and dried affording 2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-7-ylamine (194 mg, 85.2%) as a light yellow solid. mp: 221-225° C., MS: m/z=204.4 (M+H+)