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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Lithium hydroxide, monohydrate → 1-methyl-5-(2-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

HRID 1802240
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HRID 1802240 반응식
[CH3:1][N:2]1[C:6]([C:7](=[O:23])[NH:8][C:9]2[CH:14]=[CH:13][N:12]3[N:15]=[C:16]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:17]=[C:11]3[CH:10]=2)=[C:5]([C:24]([O:26]CC)=[O:25])[CH:4]=[N:3]1.O.[OH-].[Li+]>CO.O>[CH3:1][N:2]1[C:6]([C:7](=[O:23])[NH:8][C:9]2[CH:14]=[CH:13][N:12]3[N:15]=[C:16]([N:18]4[CH2:19][CH2:20][CH2:21][CH2:22]4)[N:17]=[C:11]3[CH:10]=2)=[C:5]([C:24]([OH:26])=[O:25])[CH:4]=[N:3]1
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참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 677763851-methyl-5-(2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

생성물 1

HCID 677751361-methyl-5-(2-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid수율 106%

시약·촉매·용매 2

HCID 887Methanol용매
HCID 962
Water
용매

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온도
25 °C

실험 절차

A mixture of ethyl 1-methyl-5-(2-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylate (322 mg, 840 μmol) and lithium hydroxide hydrate (141 mg, 3.36 mmol) in methanol (20 ml) and water (5 ml) was stirred for 2.5 days at 25° C. The solvent was evaporated, the residue was acidified with hydrochloric acid 37% to pH=0, the precipitated solid was filtered off, washed with water and dried affording 1-methyl-5-(2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid (316 mg, 106%) as an off-white solid. mp: >250° C., MS: m/z=356.4 (M+H+)

후처리

  1. customThe solvent was evaporated
  2. filtrationthe precipitated solid was filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-6e9a1f01e05e4493a58a46d60911cb40
출처 데이터셋
uspto-grants-2013_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08349824B2

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