Triethylamine → HCID 136337086, 화합물

HRID 1802504노트

반응식

HRID 1802504 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:28])[C:9]=1[NH:10][C:11]1[C:20]2[CH:21]=[CH:22][N:23]=[C:24]([O:25][CH2:26][CH3:27])[C:19]=2[C:18]2[C:13](=[CH:14][CH:15]=[N:16][CH:17]=2)[N:12]=1)[C:5]#[N:6].C(N(CC)CC)C.[Cl-].[OH:37][NH3+:38]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5](=[N:38][OH:37])[NH2:6])[CH:7]=[C:8]([Cl:28])[C:9]=1[NH:10][C:11]1[C:20]2[CH:21]=[CH:22][N:23]=[C:24]([O:25][CH2:26][CH3:27])[C:19]=2[C:18]2[C:13](=[CH:14][CH:15]=[N:16][CH:17]=2)[N:12]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 21645Hydroxylamine HClHCID 68424405HCID 68424405, 화합물

생성물 1

HCID 136337086HCID 136337086, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of 3,5-dichloro-4-[(10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-yl)amino]benzonitrile (Example 160, Step 1) (200 mg, 0.49 mmol) in ethanol (6 mL) was added triethylamine (0.285 mL, 2.04 mmol) and hydroxyammonium chloride (105 mg, 1.51 mmol). The reaction mixture was heated to 80° C. for 3 h in a sealed tube. After cooling to room temperature, the solid was filtered, washed with ethanol and water and dried under vacuum to afford the title compound.

후처리

  1. temperatureAfter cooling to room temperature
  2. filtrationthe solid was filtered
  3. washwashed with ethanol and water
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-c8314ed020724a75bc497468f7bdacb9
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349865B2

반응 노트

불러오는 중…