4-Bromo-2-fluorobenzene-1-sulfonyl chloride → 4-Bromo-2-fluoro-1-(phenylsulfonyl)benzene

HRID 1802839노트

반응식

HRID 1802839 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[C:4]([F:12])[CH:3]=1>[Fe](Cl)(Cl)Cl.C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)(=[O:10])=[O:9])=[C:4]([F:12])[CH:3]=1

참가 물질

4

반응물 1

HCID 27363104-Bromo-2-fluorobenzene-1-sulfonyl chloride

생성물 1

HCID 673740874-Bromo-2-fluoro-1-(phenylsulfonyl)benzene

시약·촉매·용매 2

HCID 24380Iron chloride (FeCl3)촉매HCID 241Benzene용매

실험 절차

4-Bromo-2-fluoro-benzenesulfonyl chloride (2 g), benzene (1.3 ml) and iron (III) chloride (35 mg) were heated in a sealed tube using a microwave at 200 Watts for 15 seconds. After cooling purification by flash column chromatography (eluent 20% EtOAc/Hexane) gave the subtitle compound as a solid, yield 1.8 g.

후처리

  1. customfor 15 seconds
  2. temperatureAfter cooling
  3. custompurification by flash column chromatography (eluent 20% EtOAc/Hexane)

출처 및 근거

ORD 기록
ord-c7a4c724509848a5a2f45e23ab3dae02
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349897B2

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