Ammonia → 1-(3-Methoxy-4-(6-methylpyridazin-4-yl)phenyl)thiourea

HRID 1803148

반응식

HRID 1803148 반응식
[NH3:1].[N:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]([CH3:17])[N:14]=[N:15][CH:16]=2)=[C:7]([O:18][CH3:19])[CH:6]=1)=[C:3]=[S:4]>>[CH3:19][O:18][C:7]1[CH:6]=[C:5]([NH:2][C:3]([NH2:1])=[S:4])[CH:10]=[CH:9][C:8]=1[C:11]1[CH:12]=[C:13]([CH3:17])[N:14]=[N:15][CH:16]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 866499095-(4-Isothiocyanato-2-methoxyphenyl)-3-methylpyridazine

생성물 1

HCID 866499101-(3-Methoxy-4-(6-methylpyridazin-4-yl)phenyl)thiourea수율 100%

실험 절차

Step L (5): Methanolic ammonia (2.0 M, 20 mL, 40 mmol) was added to a flask charged with 5-(4-isothiocyanato-2-methoxyphenyl)-3-methylpyridazine (650 mg, 2.53 mmol). After 4 h, the reaction mixture was concentrated in vacuo to afford 1-(3-methoxy-4-(6-methylpyridazin-4-yl)phenyl)thiourea (690 mg, 100% yield). LC-MS (M+H)+ 275.2.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-b0c012bd691049399497d45dcccf01d8
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349880B2

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