Methyl iodide → HCID 178493240, 화합물

HRID 1803177노트

반응식

HRID 1803177 반응식
[I:1][CH3:2].[F:3][C:4]1[CH:5]=[C:6]([NH:18][C:19]([NH2:21])=[S:20])[CH:7]=[C:8]([O:16][CH3:17])[C:9]=1[N:10]1[CH:14]=[N:13][C:12]([CH3:15])=[N:11]1>C(O)C>[IH:1].[F:3][C:4]1[CH:5]=[C:6]([NH:18][C:19]([S:20][CH3:2])=[NH:21])[CH:7]=[C:8]([O:16][CH3:17])[C:9]=1[N:10]1[CH:14]=[N:13][C:12]([CH3:15])=[N:11]1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 866499201-(3-fluoro-5-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)thiourea

생성물 1

HCID 178493240HCID 178493240, 화합물수율 99.3%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

Step S (4): Iodomethane (0.179 mL, 2.88 mmol) was added to a solution of 1-(3-fluoro-5-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)thiourea (0.772 g, 2.74 mmol) in absolute ethanol (50 mL). The resulting mixture was heated at 70° C. for 3 h. The crude reaction mixture was concentrated in vacuo. The residual solid was dried under high vacuum to afford methyl 3-fluoro-5-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenylcarbamimidothioate, hydroiodide (1.15 g, 2.72 mmol, 99% yield) as a yellow solid. LC-MS (M+H)+ 296.1.

후처리

  1. customThe crude reaction mixture
  2. concentrationwas concentrated in vacuo
  3. customThe residual solid was dried under high vacuum

출처 및 근거

ORD 기록
ord-eb644a26475e419f8d247f06e7ba21db
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08349880B2

반응 노트

불러오는 중…