Sodium borohydride → 1-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-ol

HRID 1803630

반응식

HRID 1803630 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:16])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1.[BH4-].[Na+]>CO>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([OH:16])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 610568711-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-one

생성물 1

HCID 627174681-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-(Furan-2-yl)-2-(3-methoxyphenyl)ethan-1-one (20 g, 92.56 mmol) was dissolved in MeOH (200 mL), and NaBH4 (3.5 g, 92.52 mmol) was slowly added to the solution at 5° C. After the reaction was completed, the solution was quenched with H2O, and the MeOH was evaporated. The residue was extracted with EtOAc and the organic layer was washed with brine, dried over MgSO4, and evaporated to give the 1-(furan-2-yl)-2-(3-methoxyphenyl)ethan-1-ol as yellow oil: 20 g (crude yield: 98%)

후처리

  1. customthe solution was quenched with H2O
  2. customthe MeOH was evaporated
  3. extractionThe residue was extracted with EtOAc
  4. washthe organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. customevaporated

출처 및 근거

ORD 기록
ord-cfc50fc9df124071abe328827218eeae
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08350090B1

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