Hydrochloric Acid → 6-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine

HRID 1803889

반응식

HRID 1803889 반응식
Cl[C:2]1[C:3]([CH3:19])=[C:4]([CH3:18])[C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[N:7]=1.[CH2:20]([N:27]1[CH2:34][CH:33]2[CH:29]([CH2:30][NH:31][CH2:32]2)[CH2:28]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.Cl>C(O)CCCC>[CH2:20]([N:27]1[CH2:34][CH:33]2[CH2:32][N:31]([C:2]3[C:3]([CH3:19])=[C:4]([CH3:18])[C:5]4[N:6]([CH:8]=[C:9]([C:11]5[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=5)[N:10]=4)[N:7]=3)[CH2:30][CH:29]2[CH2:28]1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 44543872-Benzyloctahydropyrrolo[3,4-c]pyrroleHCID 593677146-Chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine

생성물 1

HCID 594069716-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine

시약·촉매·용매 1

HCID 62761-Pentanol용매

반응 조건

온도
150 °C

실험 절차

A mixture of 3.00 g (10.9 mmol) of 6-chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine and 6.6 g (33 mmol) of 2-benzyloctahydropyrrolo[3,4-c]pyrrole in 20 mL of pentanol is heated at 150° C. for 2 days in a reactor. The medium is then poured into aqueous 1N hydrochloric acid solution. The aqueous phase is washed with ethyl acetate and then basified with sodium hydroxide.

후처리

  1. washThe aqueous phase is washed with ethyl acetate

출처 및 근거

ORD 기록
ord-dcbc1a18446b468c9f0ad9542b53480d
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354405B2

연결된 노트

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