Hydrogen Bromide → 2-Bromo-1-phenyl-2-pyrid-4-ylethanone

HRID 1803901노트

반응식

HRID 1803901 반응식
[C:1]1([C:7](=[O:15])[CH2:8][C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BrH:16].BrBr>C(O)(=O)C>[Br:16][CH:8]([C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:15]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 2871041-Phenyl-2-(4-pyridinyl)ethanone

생성물 1

HCID 134660102-Bromo-1-phenyl-2-pyrid-4-ylethanone

시약·촉매·용매 1

HCID 176Acetic Acid용매3회

반응 조건

온도
60 °C

실험 절차

To a solution of 36 g (182 mmol) of 1-phenyl-2-pyrid-4-ylethanone in 350 mL of acetic acid are successively added at room temperature 28 ml (210 mmol) of a solution containing 30% by weight of hydrobromic acid in acetic acid and 10.1 ml (197 mmol) of bromine dissolved in 50 mL of acetic acid. The solution is heated at 60° C. for one hour and then cooled. The product is precipitated by adding diethyl ether, and 63 g of a yellow solid are isolated after drying.

후처리

  1. temperaturecooled
  2. customThe product is precipitated
  3. additionby adding diethyl ether, and 63 g of a yellow solid
  4. customare isolated
  5. customafter drying

출처 및 근거

ORD 기록
ord-d2eff27045ce408dbfeac5cecbe36e99
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354405B2

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