Ethyl 4-iodobenzoate → (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1803973

반응식

HRID 1803973 반응식
I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[N:15]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1

참가 물질

3

반응물 2

HCID 142891Ethyl 4-iodobenzoateHCID 2734858(R)-4-Methyloxazolidin-2-one

생성물 1

HCID 58484719(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

실험 절차

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (1.4 mL) and (R)-4-methyloxazolidin-2-one (860 mg) described in Preparation Example 25, the title compound (0.9 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 18
  3. customdescribed in Preparation Example 25

출처 및 근거

ORD 기록
ord-e84e8c1253ee489a82819b91954e3aab
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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