Ethyl 4-iodobenzoate → (R)-4-(4-ethyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1804025노트

반응식

HRID 1804025 반응식
I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH2:13]([C@@H:15]1[CH2:19][O:18][C:17](=[O:20])[NH:16]1)[CH3:14]>>[CH2:13]([C@@H:15]1[CH2:19][O:18][C:17](=[O:20])[N:16]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1)[CH3:14]

참가 물질

3

반응물 2

HCID 142891Ethyl 4-iodobenzoateHCID 641503(4R)-4-ethyl-1,3-oxazolidin-2-one

생성물 1

HCID 58484770(R)-4-(4-ethyl-2-oxooxazolidin-3-yl)benzoic acid

실험 절차

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (1.4 mL) and (R)-4-ethyloxazolidin-2-one (979 mg) described in Preparation Example 26, the title compound (2.6 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 18
  3. customdescribed in Preparation Example 26

출처 및 근거

ORD 기록
ord-d4b4bf98a74b438da2f829860979d935
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

반응 노트

불러오는 중…