Ethyl 4-iodobenzoate → (R)-4-(2-oxo-4-propyloxazolidin-3-yl)benzoic acid

반응식

I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH2:13]([C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[NH:17]1)[CH2:14][CH3:15]>>[CH2:13]([C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1)[CH2:14][CH3:15]

참가 물질

반응물 2

HCID 142891Ethyl 4-iodobenzoate

HCID 2734859(4R)-4-Propyl-2-oxazolidinone

생성물 1

HCID 58484846(R)-4-(2-oxo-4-propyloxazolidin-3-yl)benzoic acid

실험 절차

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (3.2 mL) and (R)-4-propyloxazolidin-2-one (2.5 g) described in Preparation Example 29, the title compound (5.7 g) was obtained.

후처리

customBy reaction and treatment in the same manner
customas in Preparation Example 18
customdescribed in Preparation Example 29

출처 및 근거

ORD 기록: ord-846ed9f5f6aa4559b318bb374851e081
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08354401B2

반응 노트

불러오는 중…