Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Acetylimidazolidinone → 1-Acetyl-3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Acetylimidazolidinone | HCID 79350 | — |
| 반응물 | (2-Bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484730 | — |
| 생성물 | 1-Acetyl-3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one | HCID 58484683 | 48.6% |
반응 단계
By reaction and treatment in the same manner as in Preparation Example 12 and using (2-bromo-4-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (408.7 mg) described in Preparation Example 119 and 1-acetyl-2-imidazolidinone (128 mg), the title compound (221.5 mg) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08354401B2 |
| 출처 데이터셋 | uspto-grants-2013_01 |
| ORD ID | ord-d21bd3ebc0454c659f701522f20f091a |
| 출처 메모 | uspto-grants-2013_01 |