Sodium Hydroxide → 4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid

HRID 1804123노트

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HRID 1804123 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([N:12]2[CH2:16][CH2:15][CH2:14][S:13]2(=[O:18])=[O:17])[CH:3]=1.[OH-].[Na+]>C(O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N:12]2[CH2:16][CH2:15][CH2:14][S:13]2(=[O:17])=[O:18])[CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58484624Methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate

생성물 1

HCID 549330084-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoic acid수율 98.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

To methyl 4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)benzoate (5.57 g) described in Preparation Example 116 were added ethanol (43 mL) and 1N aqueous sodium hydroxide solution (21.7 mL) and the mixture was stirred at 60° C. for 40 min. Ethanol was evaporated and the mixture was neutralized with water and 1N hydrochloric acid under ice-cooling and the mixture was stirred. The precipitated crystal were collected by filtration to give the title compound (5.25 g).

후처리

  1. customEthanol was evaporated
  2. temperaturecooling
  3. stirringthe mixture was stirred
  4. filtrationThe precipitated crystal were collected by filtration

출처 및 근거

ORD 기록
ord-9e7de342340d441ca09e6caac18c3265
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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