4-Bromo-2-fluorobenzoic acid → (4-Bromo-2-fluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804128

반응식

HRID 1804128 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH3:12][C:13]1[CH:14]=[CH:15][C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:16]3[CH:15]=[CH:14][C:13]([CH3:12])=[CH:18][N:17]=3)[CH2:20][CH2:21]2)=[O:8])=[C:4]([F:11])[CH:3]=1

참가 물질

3

반응물 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 114807791-(5-Methyl-2-pyridinyl)piperazine

생성물 1

HCID 58484600(4-Bromo-2-fluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone수율 88.9%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-fluorobenzoic acid (1.45 g) and 1-(5-methylpyridin-2-yl)piperazine (1.06 g) described in Preparation Example 183, the title compound (2.01 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 183

출처 및 근거

ORD 기록
ord-473bee038c0a495ea5ae79571b1e382e
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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