(4R)-4-tert-Butyl-1,3-oxazolidin-2-one → 4-Tert-butyl-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}oxazolidin-2-one

HRID 1804155

반응식

HRID 1804155 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1.[C:28]([C@@H:32]1[CH2:36][O:35][C:34](=[O:37])[NH:33]1)([CH3:31])([CH3:30])[CH3:29]>>[C:28]([CH:32]1[CH2:36][O:35][C:34](=[O:37])[N:33]1[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:24]([CH3:27])(=[O:26])=[O:25])[CH:3]=1)([CH3:31])([CH3:30])[CH3:29]

참가 물질

3

반응물 2

HCID 2734860(4R)-4-tert-Butyl-1,3-oxazolidin-2-oneHCID 58484856(4-Bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

생성물 1

HCID 673814004-Tert-butyl-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}oxazolidin-2-one수율 0.9%

실험 절차

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (903 mg) described in Preparation Example 9 and (R)-4-tert-butyloxazolidin-2-one (286 mg), the title compound (9 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 1

출처 및 근거

ORD 기록
ord-1df7eed66a4a4adaba3f6c3216cb1f16
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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