Methyl iodide → (R)-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-methoxymethyloxazolidin-2-one

HRID 1804300노트

반응식

HRID 1804300 반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:32])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[C@H:27]([CH2:28][OH:29])[CH2:26][O:25][C:24]4=[O:30])=[CH:19][C:18]=3[CH3:31])=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[CH3:33]I>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:32])[C:6]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[C@H:27]([CH2:28][O:29][CH3:33])[CH2:26][O:25][C:24]4=[O:30])=[CH:19][C:18]=3[CH3:31])=[O:16])[CH2:13][CH2:14]2)=[N:7][CH:8]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 58484830(R)-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-hydroxymethyloxazolidin-2-one

생성물 1

HCID 58484750(R)-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-methoxymethyloxazolidin-2-one

실험 절차

By reaction and treatment in the same manner as in Example 73 and using (R)-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-hydroxymethyloxazolidin-2-one (150 mg) described in Example 222 and methyl iodide (21 μL), (R)-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-methoxymethyloxazolidin-2-one was obtained. The obtained compound was dissolved in a mixture of ethyl acetate and methanol, 4N hydrogen chloride/ethyl acetate was added, and the solvent was evaporated. To the obtained residue was added diisopropyl ether, and the mixture was filtered to give the title compound (140 mg).

후처리

  1. customBy reaction and treatment in the same manner as in Example 73

출처 및 근거

ORD 기록
ord-5e06b34e5eac4bd78d5e5c354dafa9eb
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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