(R)-4-Methyloxazolidin-2-one → (R)-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one

HRID 1804398

반응식

HRID 1804398 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH:25]4[CH2:27][CH2:26]4)=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[CH3:28][C@@H:29]1[CH2:33][O:32][C:31](=[O:34])[NH:30]1>>[C:7]([C:6]1[CH:9]=[C:2]([N:30]2[C@H:29]([CH3:28])[CH2:33][O:32][C:31]2=[O:34])[CH:3]=[CH:4][C:5]=1[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[C:23]([CH3:24])=[CH:22][C:21]([CH:25]3[CH2:27][CH2:26]3)=[CH:20][N:19]=2)[CH2:14][CH2:13]1)=[O:11])#[N:8]

참가 물질

3

반응물 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 584845735-Bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile

생성물 1

HCID 58484637(R)-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one

실험 절차

By reaction and treatment in the same manner as in Example 110 and using 5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (425 mg) described in Preparation Example 194 and (R)-4-methyloxazolidin-2-one. (121 mg) described in Preparation Example 25, the title compound (363 mg) was obtained.

후처리

  1. customBy reaction and treatment in the same manner as in Example 110
  2. custom(121 mg) described in Preparation Example 25

출처 및 근거

ORD 기록
ord-9575450010384f0ab491d5e9c6440974
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

연결된 노트

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