Ammonia → 3-(Propan-2-yl)benzonitrile

HRID 1804541

반응식

HRID 1804541 반응식
Br[C:2]1[CH:3]=[C:4]([CH:8]([CH3:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[Cu](C#N)[C:12]#[N:13].O.N>N1C=CC=CC=1.C1(C)C=CC=CC=1>[CH:8]([C:4]1[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=1)[C:12]#[N:13])([CH3:10])[CH3:9]

참가 물질

7

반응물 4

HCID 222AmmoniaHCID 962WaterHCID 1384991-Bromo-3-isopropylbenzeneHCID 178418260HCID 178418260, 화합물

생성물 1

HCID 2584403-(Propan-2-yl)benzonitrile

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 1140Toluene용매

실험 절차

5.15 g (25.87 mmol) m-bromo-isopropyl-benzene and 2.69 g (30.04 mmol) copper cyanide are stirred in 2.50 ml of pyridine for 24 hours at 180° C. Then 15 ml of water, 15 ml of toluene and 15 ml conc. ammonia solution are added, then the mixture is extracted. The organic phase is dried and evaporated to dryness.

후처리

  1. extractionthe mixture is extracted
  2. customThe organic phase is dried
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-656f53ae722d463c8e6a0eff14f36527
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354418B2

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