3-(Dimethylaminomethyl)benzonitrile → 1-(3-(Aminomethyl)phenyl)-N,N-dimethylmethanamine
반응식
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])[CH3:3]>N.[Ni]>[CH3:3][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][NH2:9])[CH3:1]참가 물질
4
실험 절차
7.00 g (34.95 mmol) 3-dimethylaminomethyl-benzonitrile are placed in 100 ml of methanolic ammonia solution and hydrogenated with 1.40 g Raney nickel at ambient temperature under a pressure of 3 bar. The catalyst is suction filtered, the filtrate is evaporated down. The residue is purified by chromatography.
후처리
- filtrationfiltered
- customthe filtrate is evaporated down
- customThe residue is purified by chromatography
출처 및 근거
- ORD 기록
- ord-cc3e026be93e4d69bbb85eddd8afeb61
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08354418B2
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