Iodine → Benzyl [2-(5-ethyloxazol-2-yl)ethyl]carbamate

HRID 1804554노트

반응식

HRID 1804554 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.II.C(N(CC)CC)C.O=[C:30]([CH2:48][CH3:49])[CH2:31][NH:32][C:33]([CH2:35][CH2:36][NH:37][C:38](=[O:47])[O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)=[O:34]>ClCCl>[CH2:48]([C:30]1[O:34][C:33]([CH2:35][CH2:36][NH:37][C:38](=[O:47])[O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)=[N:32][CH:31]=1)[CH3:49]

참가 물질

6

반응물 4

HCID 807IodineHCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 57637089Benzyl [2-(2-oxobutylcarbamoyl)ethyl]carbamate

생성물 1

HCID 57636953Benzyl [2-(5-ethyloxazol-2-yl)ethyl]carbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

23.07 g (49.60 mmol) PS-triphenylphosphine are suspended in 200 ml dichloromethane, 12.65 g (49.82 mmol) iodine are added. The mixture is stirred for 0.1 hours at ambient temperature, then 13.80 ml (99.28 mmol) triethylamine are added dropwise. 5.80 g (19.84 mmol) benzyl [2-(2-oxo-butylcarbamoyl)-ethyl]-carbamate dissolved in 150 ml dichloromethane are added. The reaction mixture is stirred for 72 hours at ambient temperature, then the precipitate is filtered off. The filtrate is extracted with water, the organic phase is dried and evaporated to dryness.

후처리

  1. additionare added
  2. stirringThe reaction mixture is stirred for 72 hours at ambient temperature
  3. filtrationthe precipitate is filtered off
  4. extractionThe filtrate is extracted with water
  5. customthe organic phase is dried
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-344c509a61b94b95b2a986106514681b
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354418B2

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