Hydrochloric Acid → [2-(3-Isopropyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

HRID 1804569노트

반응식

HRID 1804569 반응식
[CH:1]([C:4]1[N:8]=[C:7]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[O:6][N:5]=1)([CH3:3])[CH3:2].[ClH:19]>ClCCl>[ClH:19].[CH:1]([C:4]1[N:8]=[C:7]([CH2:9][CH2:10][NH2:11])[O:6][N:5]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric Acid2회HCID 57637051Tert-butyl[2-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate

생성물 1

HCID 46737067[2-(3-Isopropyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

900 mg (3.53 mmol) tert-butyl [2-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate are placed in 10 ml dichloromethane, 20 ml 1 molar ethereal hydrochloric acid are added. The reaction mixture is stirred for 16 hours at ambient temperature. After the further addition of 10 ml ethereal hydrochloric acid the mixture is stirred for another 72 hours at ambient temperature and 4 hours at 40° C. The suspension is evaporated down. The residue is dissolved in acetone, mixed with diethyl ether and suction filtered.

후처리

  1. stirringis stirred for another 72 hours at ambient temperature and 4 hours at 40° C
  2. customThe suspension is evaporated down
  3. dissolutionThe residue is dissolved in acetone
  4. additionmixed with diethyl ether and suction
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-bfc0e7f40ba745ce897ed442f9458fe1
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354418B2

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