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Tert-butyl 4-(1,3-thiazol-4-yl)piperidine-1-carboxylate → 4-(1,3-Thiazol-4-yl)piperidine

HRID 1804599
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HRID 1804599 반응식
[S:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[N:3]=[CH:2]1>Cl.O1CCOCC1>[S:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[N:3]=[CH:2]1
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참가 물질

4

반응물 1

HCID 53485228Tert-butyl 4-(1,3-thiazol-4-yl)piperidine-1-carboxylate

생성물 1

HCID 392362494-(1,3-Thiazol-4-yl)piperidine수율 94%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

The title compound from Step C above (280 mg, 1.04 mmol) was dissolved in 4 M HCl in dioxane (4.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-30) (237 mg, 94%). ESI-MS calculated for C8H12N2S: Exact Mass: 168.07. Found 169.07.

후처리

  1. concentrationThe product was concentrated under reduced pressure
  2. customdried under high vacuum

출처 및 근거

ORD 기록
ord-bf3b05b113874f4195859adc25366651
출처 데이터셋
uspto-grants-2013_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08354403B2

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