Dimethyl Sulfoxide → N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine

HRID 1804698

반응식

HRID 1804698 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.CS(C)=O.[CH3:15][N:16]([CH3:23])[CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.C(N(CC)CC)C>O>[CH3:15][N:16]([CH3:23])[CH:17]1[CH2:22][CH2:21][N:20]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH2:19][CH2:18]1

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 9590p-FluoronitrobenzeneHCID 417391N,N-Dimethylpiperidin-4-amine

생성물 1

HCID 11086151N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A 100 ml flask was charged with 1-fluoro-4-nitrobenzene (2.122 ml, 20 mmol), dimethylsulfoxide (30 ml), N,N-dimethylpiperidin-4-amine (2.82 g, 22.00 mmol) and triethylamine (5.58 ml, 40.0 mmol). The resulting solution was stirred at 100° C. under nitrogen for 24 hours. The reaction mixture was allowed to cool, and was poured in stirring cold water (1000 ml) and the solid collected by filtration and washed with water. The precipitate was vacuum dried to provide the title compound. MS (ESI(+)) m/e 249.9 (M+H)+.

후처리

  1. temperatureto cool
  2. additionwas poured
  3. filtrationthe solid collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-4067e18b2f174e3698967972cf5b3095
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354422B2

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