Hydrochloric Acid → HCID 67361944, 화합물

HRID 1804768노트

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HRID 1804768 반응식
C(OC([N:8]1[C@H:13]2[CH2:14][CH2:15][C@:10]([CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][C@H:21]([O:24]C(=O)C(C)(C)C)[C@@H:20]([CH3:31])[CH2:19]3)([CH:11]=[CH:12]2)[O:9]1)=O)(C)(C)C.[ClH:32]>O>[ClH:32].[CH3:31][C@@H:20]1[C@@H:21]([OH:24])[CH2:22][CH2:23][N:18]([CH2:17][CH2:16][C:10]23[CH2:15][CH2:14][CH:13]([CH2:12][CH2:11]2)[NH:8][O:9]3)[CH2:19]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67361684(1S,4S)-1-{2-[(3S,4S)-4-(2,2-Dimethyl-propionyloxy)-3-methyl-piperidin-1-yl]-ethyl}-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid tert-butyl ester

생성물 1

HCID 67361944HCID 67361944, 화합물

시약·촉매·용매 1

HCID 962Water용매

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온도
100 °C

실험 절차

(1S,4S)-1-{2-[(3S,4S)-4-(2,2-Dimethyl-propionyloxy)-3-methyl-piperidin-1-yl]-ethyl}-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid tert-butyl ester (12) (880 mg, 2 mmol) is dissolved in 20 ml of water and after addition of concentrated aqueous HCl (38%, 1.2 ml) the mixture is stirred for 16 h at 100° C. Then the mixture is evaporated to dryness. The residue s treated three times with methanol and evaporated under educed pressure. The residue is diluted with ethyl acetate, extracted with 2M K2CO3, dried over Na2SO4 and evaporated under reduced pressure. The product was used in the next step without further purification.

후처리

  1. customThen the mixture is evaporated to dryness
  2. additionThe residue s treated three times with methanol
  3. customevaporated under educed pressure
  4. additionThe residue is diluted with ethyl acetate
  5. extractionextracted with 2M K2CO3
  6. dry with materialdried over Na2SO4
  7. customevaporated under reduced pressure
  8. customThe product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-4a62558cd65e43f78387f896ed626f49
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354431B2

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