Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate → Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

HRID 1805249

반응식

HRID 1805249 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([O:14][CH3:15])=[O:13])=[CH:4][N:3]=1.[CH3:16][O-:17].[Na+]>CO>[CH3:16][O:17][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([O:14][CH3:15])=[O:13])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 3696469Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylateHCID 10942334Sodium Methoxide

생성물 1

HCID 22831728Methyl 2-methoxy-4-(trifluoromethyl)pyrimidine-5-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
110 °C

실험 절차

Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (1128 mg) was dissolved in MeOH (23 ml) before addition of sodium methoxide (380 mg), the reaction mixture was stirred for 2 hours in a sealed tube at 110° C. The solvent was evaporated, the product dissolved in ethyl acetate and washed with water, the organics were dried over Na2SO4, and concentrated in vacuo to afford title compound as a colourless oil. MS (ISP) 237.0 ([M+H]+)

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe product dissolved in ethyl acetate
  3. washwashed with water
  4. dry with materialthe organics were dried over Na2SO4
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-b44112ae04204f93bc669ab934edfad4
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354441B2

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