Hydrazine hydrate (1:1) → HCID 59436165, 화합물

HRID 1805438노트

반응식

HRID 1805438 반응식
[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:4]=[C:3]1[C:18]([O:20]C)=O.O.[NH2:23][NH2:24]>C(O)C>[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:4]=[C:3]1[C:18]([NH:23][NH2:24])=[O:20]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 1481306HCID 1481306, 화합물

생성물 1

HCID 59436165HCID 59436165, 화합물수율 60%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of methyl 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate (1.019 g, 3.42 mmol) and hydrazine monohydrate (0.3 mL, 6.19 mmol) in ethanol (10 mL) was heated under microwave conditions for 10 min at 120° C. After that time, the reaction was cooled to room temperature and the product was collected by filtration and washed with cold ethanol to give 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carbohydrazide (0.607 g, 60%) as bright orange crystals.

후처리

  1. filtrationthe product was collected by filtration
  2. washwashed with cold ethanol

출처 및 근거

ORD 기록
ord-3f012a211bc44f5bb9df473174019abd
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354411B2

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