Ethyl orthoformate → 5,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one

반응식

[NH2:1][C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[C:6]([Cl:11])[N:5]=[C:4]([Cl:12])[CH:3]=1.[CH:13](OCC)(OCC)OCC>>[Cl:11][C:6]1[C:7]2[C:8](=[O:9])[NH:10][CH:13]=[N:1][C:2]=2[CH:3]=[C:4]([Cl:12])[N:5]=1

참가 물질

반응물 2

HCID 31214Ethyl orthoformate

HCID 580930524-Amino-2,6-dichloronicotinamide

생성물 1

HCID 1357415885,7-Dichloropyrido[4,3-d]pyrimidin-4(3H)-one

반응 조건

온도: 150 °C

실험 절차

A mixture of 4-Amino-2,6-dichloronicotinamide (9.0 g, 43.7 mmol) and triethyl orthoformate (90 mL) was heated at 150° C. in a ChemGlass bomb for 6 hours and evaporated under reduced pressure to afford the title compound. 1H NMR (DMSO-d6) δ 7.72 (s, 1H), 8.31 (1H); ESI-MS m/z 216.0 (MH+).

후처리

customevaporated under reduced pressure

출처 및 근거

ORD 기록: ord-a5961e8b85bc46b0801faa7f95526ad0
출처 데이터셋: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08354526B2

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