Sodium Hydroxide → 2-Amino-3-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one
반응식
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[NH:15][CH:16]=[CH:17][C:11]=2[N:10]=[C:9]1/[N:18]=C/N(C)C)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[NH2:18][C:9]1[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:13](=[O:14])[C:12]2[NH:15][CH:16]=[CH:17][C:11]=2[N:10]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
To a mixture of (E)-N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide (21.2 g, 0.07 mol) in MeOH (382 mL) was added 3M NaOH (276 mL) and heated at 100° C. for 5 h. After completion of the reaction, the reaction mixture was cooled to 0° C. The solid was filtered (15.8 g, 91%) and used in the next step without further purification.
후처리
- customAfter completion of the reaction
- temperaturethe reaction mixture was cooled to 0° C
- filtrationThe solid was filtered (15.8 g, 91%)
- customused in the next step without further purification
출처 및 근거
- ORD 기록
- ord-99f440b2c938406bb8aebd5d42b131c8
- 출처 데이터셋
- uspto-grants-2013_01
- 특허 번호
- US08354532B2
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