Methane → HCID 178518411, 화합물

HRID 1805997노트

반응식

HRID 1805997 반응식
ClC1N=[C:4](NC2C=C(C=CC=2)C(O)=O)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2N=1.[NH2:21][C:22]([NH2:24])=[O:23].C.[OH-:26].[Na+]>>[N:21]1[C:6]2[CH:8]=[CH:9][S:10][C:5]=2[C:4]([OH:26])=[N:24][C:22]=1[OH:23]

참가 물질

5

반응물 4

HCID 297MethaneHCID 1176UreaHCID 14798Sodium HydroxideHCID 576001073-(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)benzoic acid

생성물 1

HCID 178518411HCID 178518411, 화합물수율 75%

실험 절차

10.0 g (64.0 mmol) of methylester 3-aminothiophene-2-carboxylate (I) and 19.0 g (31.60 mmol) of urea are mixed and melted for 2 hours at 200° C. After cooling, the reaction mixture is dissolved in 1 molar sodium hydroxide solution and decolorized with activated charcoal. It is filtered and the filtrate is cooled and acidified with 4M hydrochloric acid. The precipitate formed is suction filtered and dried. 8.03 g of product II (75%) is obtained as a powder.

후처리

  1. temperatureAfter cooling
  2. filtrationIt is filtered
  3. temperaturethe filtrate is cooled
  4. customThe precipitate formed
  5. filtrationfiltered
  6. customdried

출처 및 근거

ORD 기록
ord-af2a06948cb2485f8b3359544a4488d2
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354531B2

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