Diisopropylethylamine → HCID 57732731, 화합물

HRID 1806477노트

반응식

HRID 1806477 반응식
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]3[C:15](=[C:16]([C:18]([NH2:20])=[O:19])[CH:17]=2)[NH:14][CH:13]=[C:12]3[CH:21]2[CH2:26][CH2:25][N:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])[CH2:23][CH2:22]2)[CH:6]=[CH:7][CH:8]=1.[CH:32]1([S:35](Cl)(=[O:37])=[O:36])[CH2:34][CH2:33]1.CCN(C(C)C)C(C)C>CN(C=O)C.C(Cl)Cl>[CH:32]1([S:35]([NH:1][CH2:2][C:3]2[CH:4]=[C:5]([C:9]3[CH:10]=[C:11]4[C:15](=[C:16]([C:18]([NH2:20])=[O:19])[CH:17]=3)[NH:14][CH:13]=[C:12]4[CH:21]3[CH2:22][CH2:23][N:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])[CH2:25][CH2:26]3)[CH:6]=[CH:7][CH:8]=2)(=[O:37])=[O:36])[CH2:34][CH2:33]1

참가 물질

6

반응물 3

HCID 81531DiisopropylethylamineHCID 2760919Cyclopropanesulfonyl chlorideHCID 16038109HCID 16038109, 화합물

생성물 1

HCID 57732731HCID 57732731, 화합물수율 17%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 5-[3-(aminomethyl)phenyl]-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide (35 mg, 0.079 mmol) in DMF (1.0 mL) and DCM (1.0 mL) was added cyclopropanesulfonyl chloride (11 mg, 0.079 mmol) and DIEA (14 μL, 0.079 mmol). Reaction was stirred at room temperature overnight. Compound was purified by Gilson Preparatory HPLC to give 7.2 mg the title compound (17%). LC/MS=m/z 545.4 [M+H] Ret. Time: 1.94 min

후처리

  1. customReaction
  2. customCompound was purified by Gilson Preparatory HPLC

출처 및 근거

ORD 기록
ord-08f8a99897e34452894b4b878aee0812
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354406B2

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