(S)-4-(2-azido-ethyl)-2,2-dimethyl-[1,3]dioxolane → 2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethan-1-amine

HRID 1806685노트

반응식

HRID 1806685 반응식
[N:1]([CH2:4][CH2:5][C@H:6]1[CH2:10][O:9][C:8]([CH3:12])([CH3:11])[O:7]1)=[N+]=[N-]>C(OCC)(=O)C.O=[Pt]=O>[CH3:11][C:8]1([CH3:12])[O:7][C@@H:6]([CH2:5][CH2:4][NH2:1])[CH2:10][O:9]1

참가 물질

4

반응물 1

HCID 11457936(S)-4-(2-azido-ethyl)-2,2-dimethyl-[1,3]dioxolane

생성물 1

HCID 282937772-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethan-1-amine수율 88%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 8857Ethyl Acetate용매

실험 절차

Step C A suspension of (S)-4-(2-azido-ethyl)-2,2-dimethyl-[1,3]dioxolane as a yellow oil (18.7 g, 0.11 mol) and PtO2 (2.5 g) in ethyl acetate (100 mL) was vigorously shaken in a Parr under atmosphere of H2 (50 psi) for 18 h. The mixture was filtered through a short pad of celite. The filtrate was concentrated to give 2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine as a colorless oil (14 g, 88%).

후처리

  1. filtrationThe mixture was filtered through a short pad of celite
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-6b3a500e8c89462d8452648649ebde7c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354444B2

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