Acetic Acid → HCID 86641156, 화합물

HRID 1807694노트

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HRID 1807694 반응식
[F:1][C:2]([F:9])([F:8])[C:3]([CH3:7])([CH3:6])[C:4]#[N:5].C[O-].[Na+].[Na].C(O)(=O)C.[NH4+:18].[Cl-:19]>CO>[ClH:19].[F:1][C:2]([F:9])([F:8])[C:3]([CH3:7])([CH3:6])[C:4]([NH2:18])=[NH:5]

참가 물질

7

반응물 5

HCID 176Acetic AcidHCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 207676543,3,3-Trifluoro-2,2-dimethyl-propionitrile

생성물 1

HCID 86641156HCID 86641156, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
70 °C

실험 절차

3,3,3-Trifluoro-2,2-dimethyl-propionitrile (Stage 44.3) (12.40 mmol) was added to a solution of sodium methoxide (freshly prepared from 48.40 mmol sodium metal and 102 mL MeOH) at rt. After 4 h, acetic acid (48.40 mmol) and then NH4Cl (14.88 mmol) were slowly added and the reaction mixture was then heated to 70° C. for 40 h. After concentrating (40° C., 100 mbar) the reaction mixture, the residue was suspended in acetone, filtered and dried under vacuum to afford the title compound as a white solid. ESI-MS: [M+H]+ 155.

후처리

  1. concentrationAfter concentrating (40° C., 100 mbar) the reaction mixture
  2. filtrationfiltered
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-467fea5cb28d4d7295611b618060a63f
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08357707B2

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