Hydrochloric Acid → HCID 59483836, 화합물

HRID 1808378노트

반응식

HRID 1808378 반응식
Cl.[N:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:37][CH2:36][C:11]3([CH2:16][CH2:15][N:14]([C:17]([C:19]4[CH:28]=[C:27]5[C:22]([CH2:23][CH2:24][N:25](C(OC(C)(C)C)=O)[CH2:26]5)=[CH:21][CH:20]=4)=[O:18])[CH2:13][CH2:12]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>CO>[N:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:37][CH2:36][C:11]3([CH2:12][CH2:13][N:14]([C:17]([C:19]4[CH:28]=[C:27]5[C:22]([CH2:23][CH2:24][NH:25][CH2:26]5)=[CH:21][CH:20]=4)=[O:18])[CH2:15][CH2:16]3)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59483838HCID 59483838, 화합물

생성물 1

HCID 59483836HCID 59483836, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

1.25 M hydrogen chloride in methanol (15.5 ml, 19.36 mmol) was added at RT to a solution of tert-butyl 7-(9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecane-3-carbonyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1.9 g, 3.87 mmol) in methanol (4 ml), and the reaction mixture was refluxed for 1.5 h. The solvent was removed in vacuo, the residue was taken up in a small amount of ethanol (3 ml), and diethyl ether (50 ml) was added. The mixture was then cooled for 30 min in an ice bath, and the resulting solid was filtered out, washed with diethyl ether and dried in vacuo. Yield: 1.56 g (94%).

후처리

  1. temperaturethe reaction mixture was refluxed for 1.5 h
  2. customThe solvent was removed in vacuo
  3. additionwas added
  4. temperatureThe mixture was then cooled for 30 min in an ice bath
  5. filtrationthe resulting solid was filtered out
  6. washwashed with diethyl ether
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-16cb9eb322f44de5b83f7353ec04cb6d
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08357717B2

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