Imidazole → HCID 14419323, 화합물

HRID 1808670노트

반응식

HRID 1808670 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].I[CH2:9][CH2:10][CH2:11][Si:12]([O:17][CH3:18])([O:15][CH3:16])[O:13][CH3:14].ClCCl>O1CCCC1>[CH3:14][O:13][Si:12]([CH2:11][CH2:10][CH2:9][C:2]1[NH:1][CH:5]=[CH:4][N:3]=1)([O:17][CH3:18])[O:15][CH3:16]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 6344DichloromethaneHCID 24758Sodium hydrideHCID 2759373(3-Iodopropyl)trimethoxysilane

생성물 1

HCID 14419323HCID 14419323, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5 g (73 mmol) of imidazole were dissolved in 100 ml of tetrahydrofurane and 1.73 g (73 mmol) of sodium hydride were added. The suspension was stirred for 4 hours, after which 10 ml of iodopropyltrimethoxy silane (52 mmol) were added and the reaction mixture was heated under reflux for 18 hours. 15 ml of dichloromethane were then added and the reaction mixture was filtered. The filtrate was concentrated under reduced pressure and the product was distilled off at 150-155° C. at 8 mbar. The yield was 8.2 g (60%).

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux for 18 hours
  3. filtrationthe reaction mixture was filtered
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. distillationthe product was distilled off at 150-155° C. at 8 mbar

출처 및 근거

ORD 기록
ord-38adc40401b7427a9df5599cad9438fb
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08361627B2

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