Dichloromethane → HCID 178503002, 화합물

HRID 1808671노트

반응식

HRID 1808671 반응식
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[H-].[Na+].I[CH2:9][CH2:10][CH2:11][Si:12]([O:17][CH3:18])([O:15][CH3:16])[O:13][CH3:14].ClCCl>O1CCCC1>[CH3:14][O:13][Si:12]([CH2:11][CH2:10][CH2:9][C:5]1[N:4]=[CH:3][NH:2][N:1]=1)([O:17][CH3:18])[O:15][CH3:16]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 92571H-1,2,4-TriazoleHCID 24758Sodium hydrideHCID 2759373(3-Iodopropyl)trimethoxysilane

생성물 1

HCID 178503002HCID 178503002, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5 g (72 mmol) of 1,2,4-triazole were dissolved in 100 ml of absolute tetrahydrofurane and 1.73 g (72 mmol) of sodium hydride were added. The reaction mixture was stirred for 4 hours, after which 10 ml of iodopropyltrimethoxy silane (52 mmol) were added and the reaction mixture was heated under reflux for 18 hours. 20 ml of dichloromethane were then added and the reaction mixture was filtered. The solvent was removed at 150-155° C. under reduced pressure (8 mbar) and then filtered. The yield was 6.4 g (50%).

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux for 18 hours
  3. filtrationthe reaction mixture was filtered
  4. customThe solvent was removed at 150-155° C. under reduced pressure (8 mbar)
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-b9122c1815fe44b389e2c94b1dfb185b
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08361627B2

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