Benzene → 1-Methyl-1-phenyl-ethylisocyanate

HRID 1808734

반응식

HRID 1808734 반응식
C1C=CC=CC=1.[C:7]([NH2:16])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:9])[CH3:8].C(N(CC)CC)C.[C:24](Cl)(Cl)=[O:25]>C(OCC)C.C1(C)C=CC=CC=1>[N:16]([C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:9])[CH3:8])=[C:24]=[O:25]

참가 물질

7

반응물 4

HCID 241BenzeneHCID 6371PhosgeneHCID 8471TriethylamineHCID 68509Cumylamine

생성물 1

HCID 27694301-Methyl-1-phenyl-ethylisocyanate

시약·촉매·용매 2

HCID 1140Toluene용매HCID 3283Diethyl Ether용매

반응 조건

온도
60 °C

실험 절차

To a benzene (2 mL) solution of cumylamine (1.80 g, 13.3 mmol) and triethylamine (1.86 mL, 13.3 mmol) was added a 20% toluene solution of phosgene (17.5 mL, 33.3 mmol) dropwise. After completion, the reaction mixture was heated to 60° C. for 2 hours. It was then cooled to room temperature, charged with diethyl ether (20 mL), and filtered. Concentration of the filtrate in vacuo afforded the title compound. This crude product was used in the subsequent step without further purification.

후처리

  1. temperatureIt was then cooled to room temperature
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-fe3dccab2b714d998f38ddba15056b2c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08361994B2

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