Hydrochloric Acid → N-(3-[1,4]Diazepan-1-yl-4-methoxy-phenyl)-3-difluoromethoxy-benzenesulfonamide hydrochloride

HRID 1808905노트

반응식

HRID 1808905 반응식
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[C:19]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH:32]([F:34])[F:33])[CH:26]=3)(=[O:24])=[O:23])[CH:18]=[CH:17][C:16]=2[O:35][CH3:36])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:37]>ClCCl.C(OCC)C>[ClH:37].[N:11]1([C:15]2[CH:20]=[C:19]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH:32]([F:34])[F:33])[CH:26]=3)(=[O:24])=[O:23])[CH:18]=[CH:17][C:16]=2[O:35][CH3:36])[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 668200074-[5-(3-Difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

생성물 1

HCID 46937291N-(3-[1,4]Diazepan-1-yl-4-methoxy-phenyl)-3-difluoromethoxy-benzenesulfonamide hydrochloride

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

0.64 g of 4-[5-(3-difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester (1.213 mmol) were dissolved in 20 mL of dichloromethane and 1.82 mL of a 2N solution of hydrochloric acid in diethyl ether was added. After stirring at room temperature for 16 h, the solvents were evaporated, the residue redissolved in water, the aqueous phase washed with dichloromethane and then lyophilized to yield the title compound.

후처리

  1. customthe solvents were evaporated
  2. dissolutionthe residue redissolved in water
  3. washthe aqueous phase washed with dichloromethane

출처 및 근거

ORD 기록
ord-827c3813bbcf40bd8e84e843c37974f0
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362010B2

반응 노트

불러오는 중…