Sodium Hydroxide → 2-Bromo-5-ethylthiophene-3-carboxylic acid

HRID 1809081노트

반응식

HRID 1809081 반응식
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[Br:13])=[O:5])C.[OH-].[Na+]>O>[Br:13][C:7]1[S:8][C:9]([CH2:11][CH3:12])=[CH:10][C:6]=1[C:4]([OH:5])=[O:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 12588560Ethyl2-bromo-5-ethylthiophene-3-carboxylate

생성물 1

HCID 595425222-Bromo-5-ethylthiophene-3-carboxylic acid수율 70.6%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
140 °C

실험 절차

2-Bromo-5-ethyl-thiophene-3-carboxylic acid ethyl ester (0.7 g, 2.65 mmol) was dissolved in IMS (4 mL) and aqueous sodium hydroxide (1 M, 6 mL) was added. The reaction was heated to 140° C. using microwave irradiation for 10 minutes. Water (5 mL) was added and the white precipitate formed was isolated by filtration, washed with water and then dried under vacuum to give the title compound (0.44 g). 1H NMR (400 MHz, CHCl3-d): δ 7.1 (s, 1H), 2.7 (q, 2H), 1.25 (t, 3H).

후처리

  1. custommicrowave irradiation for 10 minutes
  2. customthe white precipitate formed
  3. customwas isolated by filtration
  4. washwashed with water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-b8fa958165c549af9c83f0f96aa5bf86
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362008B2

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