(2-Bromo-5-ethyl-thiophen-3-yl)-piperidin-1-yl-methanone (0.1 g, 0.33 mmol) was dissolved in DMF (3 mL). Zinc cyanide (0.34 mmol) and tetrakis-(triphenylphosphine) palladium (0) (0.017 mmol) were added and the reaction mixture heated at 100° C. for 4 hours. The mixture was cooled to ambient temperature and the reaction quenched with a mixture of 5% aqueous sodium thiosulphate and saturated aqueous potassium carbonate (1:1, 5 mL) and extracted with diethyl ether. The organic solution was dried over magnesium sulphate, filtered and the solvent removed. The product was purified by HPLC, eluting with 20%-95% acetonitrile in water (0.1% formic acid) over 30 minutes. The fractions containing the desired product were concentrated under vacuum and freeze-dried to give the title compound (0.26 mg). LCMS m/z 249.14 [M+H]+ RT=9.75 min (Analytical Method 1). 1H NMR (400 MHz, CHCl3-d): δ 6.85 (t, 1H), 3.70 (m, 2H), 3.4 (m, 2H), 2.9 (m, 2H), 1.7 (m, 4H), 1.6 (s, 2H), 1.3 (t, 3H).
